From Sunday, March 9th, to Thursday, March 13th, starting at 9:30 PM every night, there will be serious traffic delays in both the northbound and southbound directions of I-25 while CDOT dismantles the east half of the 6th Ave overpass.
Southbound: I-25 will be completely closed at 6th and traffic will be funneled into one lane and diverted on westbound 6th Ave, looped around at Federal, and sent back eastbound 6th Ave to reenter I-25.
Northbound: Traffic will be funneled into one lane and diverted onto the lanes usually devoted to southbound I-25.
Expect impacts on Federal as well. CDOT requests you use I-225 or C-470 to avoid this if you can.
More information here.